Race between virus and inflammasomes: inhibition or escape, intervention and therapy

The inflammasome is a multiprotein complex that further regulates cell pyroptosis and inflammation by activating caspase-1. assembly activation of are associated with variety diseases. Accumulative studies have shown key modulator the host’s defense response to viral infection. Indeed, it has been established occurs during At same time, host evolved corresponding mechanisms inhibit unnecessary activation. Therefore, here, we review summarize latest research progress on interaction between inflammosomes viruses, highlight inflammosome in related cells after infection, as well molecular regulatory mechanisms, elucidate effects this virus immune escape innate adaptive defenses. Finally, also discuss potential therapeutic strategies prevent and/or ameliorate infection-related diseases via targeting inflammasomes its products.